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1

Assessing the Stability of Membrane Proteins to Detect Ligand Binding Using Differential Static Light Scattering

Senisterra, G. A., Ghanei, H., Khutoreskaya, G., Dobrovetsky, E., Edwards, A. M., Prive, G. G., Vedadi, M.

Journal:

Journal of Biomolecular Screening

Year:

2010

Language:

english

File:

PDF, 550 KB

english, 2010

2

Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response

Alice T. McDuffee, Guillermo Senisterra, Steven Huntley, James R. Lepock, Konjeti R. Sekhar, Michael J. Meredith, Michael J. Borrelli, Jason D. Morrow, Michael L. Freeman

Journal:

Journal of Cellular Physiology

Year:

1997

Language:

english

File:

PDF, 206 KB

english, 1997

3

Characterization of a signal generated by oxidation of protein thiols that activates the heat shock transcription factor

Michael L. Freeman, Michael J. Borrelli, Khalid Syed, Guillermo Senisterra, Diane M. Stafford, James R. Lepock

Journal:

Journal of Cellular Physiology

Year:

1995

Language:

english

File:

PDF, 1.12 MB

english, 1995

4

Lysophospholipids as Natural Molecular Harpoons Sensing Defects at Lipid Membranes

E.A. Disalvo, L.I. Viera, L.S. Bakas, G.A. Senisterra

Journal:

Journal of Colloid and Interface Science

Year:

1996

Language:

english

File:

PDF, 178 KB

english, 1996

5

Phase behaviour of heteroacid phosphatidylserines and cholesterol

Diana Bach, Ellen Wachtel, Nina Borochov, Guillermo Senisterra, Richard M. Epand

Journal:

Chemistry and Physics of Lipids

Year:

1992

Language:

english

File:

PDF, 651 KB

english, 1992

6

Changes in the optical properties of liposome dispersions in relation to the interlamellar distance and solute interaction

L.I Viera, G.A Senisterra, E.A Disalvo

Journal:

Chemistry and Physics of Lipids

Year:

1996

Language:

english

File:

PDF, 755 KB

english, 1996

7

TheCryptosporidium parvumKinome

Jennifer D Artz, Amy K Wernimont, Abdellah Allali-Hassani, Yong Zhao, Mehrnaz Amani, Yu-Hui Lin, Guillermo Senisterra, Gregory A Wasney, Oleg Fedorov, Oliver King, Annette Roos, Vlad V Lunin, Wei Qiu,

Journal:

Year:

2011

Language:

english

File:

PDF, 1.69 MB

english, 2011

8

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

Wernimont, Amy K, Artz, Jennifer D, Finerty, Patrick, Lin, Yu-Hui, Amani, Mehrnaz, Allali-Hassani, Abdellah, Senisterra, Guillermo, Vedadi, Masoud, Tempel, Wolfram, Mackenzie, Farrell

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 973 KB

english, 2010

9

Small-Molecule Ligands of Methyl-Lysine Binding Proteins

Herold, J. Martin, Wigle, Tim J., Norris, Jacqueline L., Lam, Robert, Korboukh, Victoria K., Gao, Cen, Ingerman, Lindsey A., Kireev, Dmitri B., Senisterra, Guillermo, Vedadi, Masoud

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.53 MB

english, 2011

10

Role of Membrane Defects in the Regulation of the Activity of Protein Kinase C

G. Senisterra, R.M. Epand

Journal:

Archives of Biochemistry and Biophysics

Year:

1993

File:

PDF, 513 KB

1993

11

Calcium-Independent Activation of Protein Kinase C by the Dianionic Form of Phosphatidic Acid

G.A. Senisterra, L.C.M. Vangorkom, R.M. Epand

Journal:

Biochemical and Biophysical Research Communications

Year:

1993

File:

PDF, 199 KB

1993

12

Osmotic dependence of the lysophosphatidylcholine lytic action on liposomes in the gel state

G.A. Senisterra, E.A. Disalvo, J.J. Gagliardino

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1988

Language:

english

File:

PDF, 582 KB

english, 1988

13

Effect of insulin on the lytic action of lysophosphatidylcholine in lipid bilayers

G.A. Senisterra, J.J. Gagliardino, E.A. Disalvo

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1991

Language:

english

File:

PDF, 733 KB

english, 1991

14

Dual modulation of protein kinase C activity by sphingosine

Guillermo Senisterra, Richard M. Epand

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 400 KB

english, 1992

15

Permeability of lipid membranes revised in relation to freeze-thaw processes

A.C. Biondi, G.A. Senisterra, E.A. Disalvo

Journal:

Year:

1992

Language:

english

File:

PDF, 738 KB

english, 1992

16

Biophysical characterization of recombinant proteins: A key to higher structural genomics success

Masoud Vedadi, Cheryl H. Arrowsmith, Abdellah Allali-Hassani, Guillermo Senisterra, Gregory A. Wasney

Journal:

Journal of Structural Biology

Year:

2010

Language:

english

File:

PDF, 681 KB

english, 2010

17

An Allosteric Inhibitor of Protein Arginine Methyltransferase 3

Alena Siarheyeva, Guillermo Senisterra, Abdellah Allali-Hassani, Aiping Dong, Elena Dobrovetsky, Gregory A. Wasney, Irene Chau, Richard Marcellus, Taraneh Hajian, Feng Liu, Ilia Korboukh, David Smil,

Journal:

Year:

2012

Language:

english

File:

PDF, 737 KB

english, 2012

18

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M., Wasney, Gregory A., Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmit

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.14 MB

english, 2009

19

Structural and Mechanistic Analysis of a Novel Class of Shikimate Dehydrogenases: Evidence for a Conserved Catalytic Mechanism in the Shikimate Dehydrogenase Family

Peek, James, Lee, John, Hu, Shi, Senisterra, Guillermo, Christendat, Dinesh

Journal:

Year:

2011

Language:

english

File:

PDF, 4.51 MB

english, 2011

20

Thermal Denaturation Assays in Chemical Biology

Senisterra, Guillermo, Chau, Irene, Vedadi, Masoud

Journal:

Assay and Drug Development Technologies

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

21

Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.

Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M., Wigle, Tim J., Wasney, Gregory A., Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L., Kireev, Dm

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.61 MB

english, 2010

22

Crystal Structures of Apo Centaurin Alpha1 and its Complex With Phosphatidylinositol 3,4,5-triphosphate

Park, Hee-Won, Tong, Yufeng, Tempel, Wolfram, Wang, Hui, Shen, Limin, Senisterra, Guillermo A., MacKenzie, Farrell

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

23

Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1

Qin, Su, Liu, Yanli, Tempel, Wolfram, Eram, Mohammad S., Bian, Chuanbing, Liu, Ke, Senisterra, Guillermo, Crombet, Lissete, Vedadi, Masoud, Min, Jinrong

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 1.85 MB

english, 2014

24

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

Bolshan, Yuri, Getlik, Matthäus, Kuznetsova, Ekaterina, Wasney, Gregory A., Hajian, Taraneh, Poda, Gennadiy, Nguyen, Kong T., Wu, Hong, Dombrovski, Ludmila, Dong, Aiping, Senisterra, Guillermo, Schapi

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.41 MB

english, 2013

25

Destabilization of the Ca 2+ -ATPase of Sarcoplasmic Reticulum by Thiol-Specific, Heat Shock Inducers Results in Thermal Denaturation at 37 °C †

Senisterra, Guillermo A., Huntley, Steven A., Escaravage, Michel, Sekhar, Konjeti R., Freeman, Michael L., Borrelli, Michael, Lepock, James R.

Journal:

Year:

1997

Language:

english

File:

PDF, 213 KB

english, 1997

26

Thermal destabilization of transmembrane proteins by local anaesthetics

G. A. Senisterra, J. R. Lepock,

Journal:

International Journal of Hyperthermia

Year:

2000

Language:

english

File:

PDF, 346 KB

english, 2000

27

287 The discovery and optimization of small molecule antagonists of the WDR5–MLL interaction

Al-Awar, R., Al-Awar, R.S., Getlik, M., Smil, D., Bolshan, Y., Poda, G., Senisterra, G., Wu, H., Allali-Hassani, A., Wasney, G.A., Barsyte-Lovejoy, D., Dombrovski, L., Dong, A., He, H., Seitova, A., C

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 62 KB

english, 2014

28

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Barsyte-Lovejoy, D., Li, F., Oudhoff, M. J., Tatlock, J. H., Dong, A., Zeng, H., Wu, H., Freeman, S. A., Schapira, M., Senisterra, G. A., Kuznetsova, E., Marcellus, R., Allali-Hassani, A., Kennedy, S.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

29

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

Eram, M. S., Bustos, S. P., Lima-Fernandes, E., Siarheyeva, A., Senisterra, G., Hajian, T., Chau, I., Duan, S., Wu, H., Dombrovski, L., Schapira, M., Arrowsmith, C. H., Vedadi, M.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 2.64 MB

english, 2014

30

Screening for Ligands Using a Generic and High-Throughput Light-Scattering-Based Assay

Senisterra, G. A., Markin, E., Yamazaki, K., Hui, R., Vedadi, M., Awrey, D. E.

Journal:

Journal of Biomolecular Screening

Year:

2006

Language:

english

File:

PDF, 237 KB

english, 2006

31

Crystal Structures of Human Pantothenate Kinases: INSIGHTS INTO ALLOSTERIC REGULATION AND MUTATIONS LINKED TO A NEURODEGENERATION DISORDER

Hong, B. S., Senisterra, G., Rabeh, W. M., Vedadi, M., Leonardi, R., Zhang, Y.-M., Rock, C. O., Jackowski, S., Park, H.-W.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 614 KB

english, 2007

32

Application of High-Throughput Isothermal Denaturation to Assess Protein Stability and Screen for Ligands

Senisterra, G. A., Soo Hong, B., Park, H.-W., Vedadi, M.

Journal:

Journal of Biomolecular Screening

Year:

2008

Language:

english

File:

PDF, 352 KB

english, 2008

33

Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreenTM-Based Assay for Antagonists of Methyl-Lysine Binding Proteins

Wigle, T. J., Herold, J. M., Senisterra, G. A., Vedadi, M., Kireev, D. B., Arrowsmith, C. H., Frye, S. V., Janzen, W. P.

Journal:

Journal of Biomolecular Screening

Year:

2010

Language:

english

File:

PDF, 1.18 MB

english, 2010

34

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Pizarro, Juan Carlos, Hills, Tanya, Senisterra, Guillermo, Wernimont, Amy K., Mackenzie, Claire, Norcross, Neil R., Ferguson, Michael A. J., Wyatt, Paul G., Gilbert, Ian H., Hui, Raymond, Pollastri, M

Journal:

PLoS Neglected Tropical Diseases

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

35

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

Senisterra, Guillermo, Wu, Hong, Allali‑Hassani, Abdellah, Wasney, Gregory A., Barsyte‑Lovejoy, Dalia, Dombrovski, Ludmila, Dong, Aiping, Nguyen, Kong T., Smil, David, Bolshan, Yuri, Hajian, Taraneh,

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

36

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin 1

Tong, Y., Tempel, W., Wang, H., Yamada, K., Shen, L., Senisterra, G. A., MacKenzie, F., Chishti, A. H., Park, H.-W.

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.42 MB

english, 2010

37

The Nuclear Matrix Is a Thermolabile Cellular Structure

James R. Lepock, Harold E. Frey, Miriam L. Heynen, Guillermo A. Senisterra and Raymond L. Warters

Journal:

Cell Stress and Chaperones

Year:

2001

Language:

english

File:

PDF, 509 KB

english, 2001

38

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Eram, Mohammad S., Shen, Yudao, Szewczyk, Magdalena M., Wu, Hong, Senisterra, Guillermo, Li, Fengling, Butler, Kyle V., Kaniskan, H. Ümit, Speed, Brandon A., dela Seña, Carlo, Dong, Aiping, Zeng, Hong

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.18 MB

english, 2015

39

Variation of wood Density and fibre length in six Willow Clones (Salix SPP.)

Senisterra, Gabriela, Marlats, Raúl, Monteoliva, Silvia

Journal:

Year:

2005

Language:

english

File:

PDF, 141 KB

english, 2005

40

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor

Ferreira de Freitas, Renato, Eram, Mohammad S., Szewczyk, Magdalena M., Steuber, Holger, Smil, David, Wu, Hong, Li, Fengling, Senisterra, Guillermo, Dong, Aiping, Brown, Peter J., Hitchcock, Marion, M

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 3.43 MB

english, 2016

41

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)

Getlik, Matthäus, Smil, David, Zepeda-Velázquez, Carlos, Bolshan, Yuri, Poda, Gennady, Wu, Hong, Dong, Aiping, Kuznetsova, Ekaterina, Marcellus, Richard, Senisterra, Guillermo, Dombrovski, Ludmila, Ha

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.82 MB

english, 2016

42

Destabilization and Denaturation of Cellular Protein by Glutathione Depletion

Michael L. Freeman, Steven A. Huntley, Michael J. Meredith, Guillermo A. Senisterra and James Lepock

Journal:

Cell Stress and Chaperones

Year:

1997

Language:

english

File:

PDF, 500 KB

english, 1997

43

Thermal Activation of the Bovine Hsc70 Molecular Chaperone at Physiological Temperatures: Physical Evidence of a Molecular Thermometer

Sau-Mei Leung, Guillermo Senisterra, Kenneth P. Ritchie, Seth E. Sadis, James R. Lepock and Lawrence E. Hightower

Journal:

Cell Stress and Chaperones

Year:

1996

Language:

english

File:

PDF, 929 KB

english, 1996

44

Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6

Shen, Yudao, Szewczyk, Magdalena M, Eram, Mohammad S., Smil, David, Kaniskan, H. Ümit, de Freitas, Renato Ferreira, Senisterra, Guillermo, Li, Fengling, Schapira, Matthieu, Brown, Peter J., Arrowsmith

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 8.64 MB

english, 2016

45

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

Allali-Hassani, Abdellah, Wasney, Gregory A., Chau, Irene, Hong, Bum Soo, Senisterra, Guillermo, Loppnau, Peter, Shi, Zhen, Moult, John, Edwards, Aled M., Arrowsmith, Cheryl H., Park, Hee Won, Schapir

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 688 KB

english, 2009

46

Conformational dynamics of the TTD-PHD histone reader module of UHRF1 reveals multiple histone binding states, allosteric regulation and druggability

Houliston, R. Scott, Lemak, Alexander, Iqbal, Aman, Ivanochko, Danton, Duan, Shili, Kaustov, Lilia, Ong, Michelle S., Fan, Lixin, Senisterra, Guillermo, Brown, Peter J., Wang, Yun-Xing, Arrowsmith, Ch

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 3.25 MB

english, 2017

47

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain

Senisterra, Guillermo, Zhu, Hugh Y., Luo, Xiao, Zhang, Hailong, Xun, Guoliang, Lu, Chunliang, Xiao, Wen, Hajian, Taraneh, Loppnau, Peter, Chau, Irene, Li, Fengling, Allali-Hassani, Abdellah, Atadja, P

Journal:

Year:

2018

Language:

english

File:

PDF, 2.03 MB

english, 2018

48

Estimation of soil erosionability in the stream basin of Pillahuinco Grande, Province of Buenos Aires, Argentina

Gaspari, Fernanda J, Rodríguez Vagaría, Alfonso M, Senisterra, Gabriela E

Journal:

Ciência e investigación agraria

Year:

2009

Language:

english

File:

PDF, 373 KB

english, 2009

49

Effects of 4-h ischemia and 1-h reperfusion on rat muscle sarcoplasmic reticulum function

Tupling, R., Green, H., Senisterra, G., Lepock, J., McKee, N.

Journal:

American Journal of Physiology-Endocrinology and Metabolism

Year:

2001

Language:

english

File:

PDF, 350 KB

english, 2001

50

Effects of ischemia on sarcoplasmic reticulum Ca 2+ uptake and Ca 2+ release in rat skeletal muscle

Tupling, R., Green, H., Senisterra, G., Lepock, J., McKee, N.

Journal:

American Journal of Physiology-Endocrinology and Metabolism

Year:

2001

Language:

english

File:

PDF, 195 KB

english, 2001

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